Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
نویسندگان
چکیده
منابع مشابه
Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty in dissecting both directional signaling events simultaneously in vivo, most biological activities caused by CD137-CD137L interactions are considered as results from signaling events of the CD137 ...
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CD137 is a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Interaction of CD137 with its ligand (CD137L) affects the apoptosis, proliferation and differentiation of immune cells. Interestingly, the CD137 receptor/ligand system involves the bi-directional transduction of signals. The expression of CD137 and its ligand is not restricted to immune organs, but can also...
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Although the majority of research on CD137 has been directed to T cells, it is becoming clear that this molecule has distinct functions in other lineages of cells, including non-hematopoietic cells. In particular, emerging evidence suggests that the CD137-its ligand (CD137L) network involving immune cells and non-immune cells, directly or indirectly regulates inflammation in both positive and n...
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ژورنال
عنوان ژورنال: Immune Network
سال: 2015
ISSN: 1598-2629,2092-6685
DOI: 10.4110/in.2015.15.3.121